Environmental Rheumatology
Stressful life events are associated with the diagnosis of systemic autoimmune rheumatic diseases among adults
I. Bauer Ventura1, M.E. Goldberg2, A. Schiffenbauer3, M. Shi4, R. Volochayev5, S.H. Jackson6, A. Jansen7, N. Bayat8, P. Noroozi Farhadi9, C.G. Parks10, C.R. Weinberg11, A. Picardi12, F.W. Miller13, L.G. Rider14
- Section of Rheumatology, Department of Medicine, University of Chicago, IL, USA.
- Environmental Autoimmunity Group, National Institute of Environmental Health Sciences, National Institutes of Health, Bethesda, MD, and Research Triangle Park, NC, USA.
- Environmental Autoimmunity Group, National Institute of Environmental Health Sciences, National Institutes of Health, Bethesda, MD, and Research Triangle Park, NC, USA.
- Biostatistics and Computational Biology Branch, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC, USA.
- Environmental Autoimmunity Group, National Institute of Environmental Health Sciences, National Institutes of Health, Bethesda, MD, and Research Triangle Park, NC, USA.
- National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, MD, USA.
- Environmental Autoimmunity Group, National Institute of Environmental Health Sciences, National Institutes of Health, Bethesda, MD, and Research Triangle Park, NC, USA.
- Environmental Autoimmunity Group, National Institute of Environmental Health Sciences, National Institutes of Health, Bethesda, MD, and Research Triangle Park, NC, USA, and Social Scientific System Inc, a DLH holding company.
- Environmental Autoimmunity Group, National Institute of Environmental Health Sciences, National Institutes of Health, Bethesda, MD, and Research Triangle Park, NC, USA.
- Epidemiology Branch, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC, USA.
- Biostatistics and Computational Biology Branch, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC, USA.
- Centre for Behavioural Sciences and Mental Health, Italian National Institute of Health, Rome, Italy.
- Environmental Autoimmunity Group, National Institute of Environmental Health Sciences, National Institutes of Health, Bethesda, MD, and Research Triangle Park, NC, USA.
- Environmental Autoimmunity Group, National Institute of Environmental Health Sciences, National Institutes of Health, Bethesda, MD, and Research Triangle Park, NC, USA. riderl@mail.nih.gov
CER18056
2025 Vol.43, N°1
PI 0021, PF 0027
Environmental Rheumatology
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PMID: 39846368 [PubMed]
Received: 07/08/2024
Accepted : 02/01/2025
In Press: 23/01/2025
Published: 23/01/2025
Abstract
OBJECTIVES:
To assess the association between life events and subsequent diagnosis of systemic autoimmune rheumatic diseases (SARDs) by comparing siblings discordant for SARDs and unrelated controls.
METHODS:
Life events 12 months prior to SARD diagnosis/reference date were queried using the Interview for Recent Life Events in 227 adults (96 probands with SARDs, 78 siblings, 53 controls). Probands were matched by age, sex, and race with their unaffected siblings or with unrelated controls. Logistic regression was used to calculate the relative odds of SARDs in relation to life events scores, adjusting for age, sex, race/ethnicity, education, and ever smoking.
RESULTS:
The study identified consistent trends of probands reporting greater numbers of total and highly stressful events, and higher stress ratings than their unaffected siblings. Probands reported greater numbers and higher stress ratings of total, uncontrollable, and undesirable events compared to unrelated controls (p<0.001–0.024). The number of highly stressful events and the scores of weighted major events were also greater in probands and siblings compared to unrelated controls (p<0.001–0.046). The number of total, major, uncontrollable, undesirable, and highly stressful life events (OR range 1.31-1.64, p-value range 0.001–0.049), along with their corresponding stress ratings (OR range 1.22-1.51, p-value range <0.001–0.016), were associated with higher odds of SARD diagnosis, based on probands compared to controls.
CONCLUSIONS:
This case-control study of life events preceding SARDs diagnosis using a validated life events questionnaire provides support for an aetiologic role of negative life events and psychological stress in SARDs among adults.
