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Non-negligible prevalence of focal lymphocytic sialadenitis in minor salivary glands of non-Sjögren's disease individuals
S. Liu1, C. Chen2, Q. Zheng3, H. Sun4, C. Yang5, B. Wang6, G. Shi7, D. Xu8, M. Shen9
- Department of Rheumatology and Immunology, Nanjing First Hospital, Nanjing Medical University, Nanjing, China.
- Department of Rheumatology and Immunology, Guangzhou First People's Hospital, Guangzhou, China.
- Department of Rheumatology and Clinical Immunology, The First Affiliated Hospital, Fujian Medical University, Fuzhou, China.
- Centre of Precision Pathologic Diagnosis, Weifang People's Hospital, Shandong Second Medical University, Weifang, China.
- Department of Rheumatology and Immunology, Weifang People's Hospital, Shandong Second Medical University, Weifang, China.
- Central Laboratory, Weifang People's Hospital, Shandong Second Medical University, Weifang, China. rmyywangbin@sdsmu.edu.cn
- Department of Rheumatology and Clinical Immunology, The First Affiliated Hospital of Xiamen University, Xiamen; and Xiamen Key Laboratory of Rheumatology and Clinical Immunology, Xiamen, China.
- Department of Rheumatology and Immunology, Weifang People’s Hospital, Shandong Second Medical University, Weifang; and Central Laboratory, Weifang People’s Hospital, Shandong Second Medical University, Weifang, China.
- Department of Rheumatology and Immunology, Nanjing First Hospital, Nanjing Medical University, Nanjing, China. shenminning@126.com
CER18201
2024 Vol.42, N°12
PI 2499, PF 2506
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PMID: 39699870 [PubMed]
Received: 30/09/2024
Accepted : 02/12/2024
In Press: 19/12/2024
Published: 19/12/2024
Abstract
OBJECTIVES:
Focal lymphocytic sialadenitis (FLS) in minor salivary gland biopsy (MSGB) has long been regarded as a histologic hallmark of Sjögren’s disease (SjD), but it can also occur in non-SjD individuals. This study aimed to define the prevalence of FLS in labial minor salivary glands of non-SjD individuals via both an autopsy study and a meta-analysis.
METHODS:
A total of 214 genotype-tissue expression (GTEx) volunteers was included in the autopsy study, and FLS in labial minor salivary gland was evaluated. A meta-analysis was also performed to comprehensively define the prevalence of FLS in labial minor salivary glands of non-SjD individuals.
RESULTS:
In the autopsy study of 214 GTEx volunteers, the frequency of FLS in labial minor salivary glands was 13.1%. GTEx volunteers aged 60 years and older demonstrated a greater prevalence of FLS compared to those volunteers younger than 60 years (20.3% vs. 9.7%, p=0.03). In the meta-analysis, a total of 8 eligible studies involving 917 labial minor salivary gland samples were included. The pooled prevalence of FLS in labial minor salivary glands of non-SjD individuals was 6.2%. In the subgroup analysis by gender, the pooled prevalence of FLS in labial minor salivary glands for female and male non-SjD individuals was 10.4% and 5.0%, respectively.
CONCLUSIONS:
This study provides compelling epidemiological evidence for the considerably high prevalence of FLS in minor salivary glands of non-SjD individuals. The clinical significance of FLS should be cautiously considered when MSGB is used to confirm seronegative SjD.
