impact factor, citescore
logo
 

Full Papers

 

Matrix metalloproteinase-12, an indicator potentially contributing to the differential diagnosis and activity assessment of retroperitoneal fibrosis


1, 2, 3, 4, 5, 6, 7

 

  1. Department of Research and Education, Peking University International Hospital, Beijing; and Peking University Eighth Clinical Medical School, Beijing, China.
  2. Department of Clinical Laboratory, Peking University International Hospital, Beijing, China.
  3. Department of Rheumatology and Immunology, Peking University International Hospital, Beijing, China.
  4. Department of Rheumatology, Peking University People’s Hospital, Beijing; and Department of Rheumatology, Peking University Third Hospital, Beijing, China.
  5. Department of Rheumatology, Peking University Third Hospital, Beijing, China.
  6. Department of Retroperitoneal Tumour Surgery, Peking University International Hospital, Beijing, China. liushibo@pkuih.edu.cn
  7. Peking University Eighth Clinical Medical School, Beijing; and Department of Rheumatology and Immunology, Peking University International Hospital, Beijing, China. gaohui@pkuih.edu.cn

CER18227
Full Papers

purchase article

PMID: 39977006 [PubMed]

Received: 11/10/2024
Accepted : 03/02/2025
In Press: 20/02/2025

Abstract

OBJECTIVES:
We aimed to find a diagnostic indicator that contributed to differential diagnosis and activity assessment of retroperitoneal fibrosis (RPF).
METHODS:
We analysed the expression of MMP-12 in pathological tissues and peripheral blood, and explored their correlations with clinical, laboratory, radical and pathological parameters.
RESULTS:
The positive rate of MMP-12 in pathological tissues was significantly higher than that in the healthy controls. It was positively correlated with the positive rates of mTOR, CXCR5, IL-13 in the germinal centres (GCs) and MMP-12, IL-13 in the periphery. The parametric estimate of the area under the ROC curve of the positive rate and its 95% confidence interval were 0.875 and 0.673 ~1.000. The cut-off value and sensitivity and specificity were 16.395%, 0.938 and 0.750. Thickness of RPF mass was more severe in MMP-12 positive group based on this cut-off value. Although the concentration of MMP-12 in peripheral blood did not increase significantly, it was positively correlated with time before treatment and the positive rate of CXCR5 in the GCs.
CONCLUSIONS:
The positive rate of MMP-12 in the GCs of pathological tissues is a potential marker that contributes to the differential diagnosis of RPF and might be associated with the degree of fibrosis, although MMP-12 in the peripheral blood was not very helpful for disease diagnosis and monitoring of treatment effects. MMP-12 had the potential to become an indicator for the differential diagnosis RPF and monitoring the disease process.

DOI: https://doi.org/10.55563/clinexprheumatol/ys972g

Rheumatology Article