Full Papers
Matrix metalloproteinase-12, an indicator potentially contributing to the differential diagnosis and activity assessment of retroperitoneal fibrosis
T. Zheng1, X. Zhang2, J. Gao3, X. Zhang4, J. Zhao5, S. Liu6, H. Gao7
- Department of Research and Education, Peking University International Hospital, Beijing; and Peking University Eighth Clinical Medical School, Beijing, China.
- Department of Clinical Laboratory, Peking University International Hospital, Beijing, China.
- Department of Rheumatology and Immunology, Peking University International Hospital, Beijing, China.
- Department of Rheumatology, Peking University People’s Hospital, Beijing; and Department of Rheumatology, Peking University Third Hospital, Beijing, China.
- Department of Rheumatology, Peking University Third Hospital, Beijing, China.
- Department of Retroperitoneal Tumour Surgery, Peking University International Hospital, Beijing, China. liushibo@pkuih.edu.cn
- Peking University Eighth Clinical Medical School, Beijing; and Department of Rheumatology and Immunology, Peking University International Hospital, Beijing, China. gaohui@pkuih.edu.cn
CER18227
2025 Vol.43, N°5
PI 0924, PF 0930
Full Papers
PMID: 39977006 [PubMed]
Received: 11/10/2024
Accepted : 03/02/2025
In Press: 20/02/2025
Published: 08/05/2025
Abstract
OBJECTIVES:
We aimed to find a diagnostic indicator that contributed to differential diagnosis and activity assessment of retroperitoneal fibrosis (RPF).
METHODS:
We analysed the expression of MMP-12 in pathological tissues and peripheral blood, and explored their correlations with clinical, laboratory, radical and pathological parameters.
RESULTS:
The positive rate of MMP-12 in pathological tissues was significantly higher than that in the healthy controls. It was positively correlated with the positive rates of mTOR, CXCR5, IL-13 in the germinal centres (GCs) and MMP-12, IL-13 in the periphery. The parametric estimate of the area under the ROC curve of the positive rate and its 95% confidence interval were 0.875 and 0.673 ~1.000. The cut-off value and sensitivity and specificity were 16.395%, 0.938 and 0.750. Thickness of RPF mass was more severe in MMP-12 positive group based on this cut-off value. Although the concentration of MMP-12 in peripheral blood did not increase significantly, it was positively correlated with time before treatment and the positive rate of CXCR5 in the GCs.
CONCLUSIONS:
The positive rate of MMP-12 in the GCs of pathological tissues is a potential marker that contributes to the differential diagnosis of RPF and might be associated with the degree of fibrosis, although MMP-12 in the peripheral blood was not very helpful for disease diagnosis and monitoring of treatment effects. MMP-12 had the potential to become an indicator for the differential diagnosis RPF and monitoring the disease process.
