Review
Harnessing extracellular vesicles for biomarker discovery in psoriatic disease
C.R. Bryan1, T. Grohmann2, O. Fitzgerald3, S.R. Pennington4
- UCD Conway Institute for Biomolecular Research, School of Medicine, University College Dublin, Ireland.
- UCD Conway Institute for Biomolecular Research, School of Medicine, University College Dublin, Ireland.
- UCD Conway Institute for Biomolecular Research, School of Medicine, University College Dublin, Ireland.
- UCD Conway Institute for Biomolecular Research, School of Medicine, University College Dublin, Ireland. stephen.pennington@ucd.ie
CER18242
Review
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Received: 17/10/2024
Accepted : 02/05/2025
In Press: 26/06/2025
Abstract
Extracellular vesicles (EVs) have emerged as potent mediators of inter-cellular communication. These nano-sized structures encapsulate bioactive molecules that reflect the pathophysiological state of the originating cell, offering potential as both biomarkers and therapeutic targets. Mass spectrometry (MS) techniques have facilitated in-depth profiling of the EV proteome, unveiling valuable insights into disease mechanisms and progression. Specifically, the protein composition of EVs is indicative of the cell of origin, and those derived from diseased patients have shown distinct proteomic signatures compared to healthy individuals. Given the role of EV in cell-to-cell communication and immune modulation, studying their proteomic content can provide insights into disease pathogenesis and aid in developing new diagnostic strategies to manage conditions such as psoriatic arthritis. Identifying EV protein biomarkers could potentially lead to the development of non-invasive diagnostic and prognostic tests, aiding early detection and monitoring of disease progression.
