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Psoriatic arthritis phenotype may vary depending on whether the skin or joint domain appears first or whether both appear simultaneously

1, 2, 3, 4, 5, 6, 7, 8, 9, 10

 

  1. Rheumatology Division, Central University Hospital of Asturias, Oviedo; Department of Medicine, Oviedo University School of Medicine, Oviedo; Translational Immunology Division, and Biostatistics Platform, Health Research Institute of the Principality of Asturias (ISPA), Oviedo, Spain. rubenque7@yahoo.es
  2. Rheumatology Division, Central University Hospital of Asturias, Oviedo, Spain.
  3. Rheumatology Division, Central University Hospital of Asturias, Oviedo, Spain.
  4. Rheumatology Division, Central University Hospital of Asturias, Oviedo, Spain.
  5. Rheumatology Division, Central University Hospital of Asturias, Oviedo, Spain.
  6. Rheumatology Division, Central University Hospital of Asturias, Oviedo, Spain.
  7. Rheumatology Division, Central University Hospital of Asturias, Oviedo, Spain.
  8. Rheumatology Division, Central University Hospital of Asturias, Oviedo, Spain.
  9. Biostatistics Platform, Health Research Institute of the Principality of Asturias (ISPA), Oviedo, Spain.
  10. Rheumatology Division, Central University Hospital of Asturias, Oviedo, Spain.

CER18322
2025 Vol.43, N°5
PI 0889, PF 0896
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PMID: 40095701 [PubMed]

Received: 09/11/2024
Accepted : 15/01/2025
In Press: 05/03/2025
Published: 08/05/2025

Abstract

OBJECTIVES:
We aimed to analyse psoriatic arthritis (PsA) features based on psoriasis-arthritis lag times: simultaneous (S), psoriasis first (PF), arthritis first (AF).
METHODS:
We carried out an inception cohort study involving 340 PsA patients. Phenotypic differences between patients were analysed based on the three disease latency models identified in the study. A post-hoc correction of significant p-values was applied by the Benjamini-Hochberg method.
RESULTS:
Forty-five (13.2%) patients had S onset, 97 (28.5%) manifested AF, while in 198 (58.2%) psoriasis appeared first. Lag times were markedly different between PF (16.3 ±12.4 years) and AF (5.4 ±2.8 years) groups, p<0.001. The AF group presented less frequently the classic arthritogenic psoriasis pattern: nail (18.8%, p<0.001), scalp (28.1%, p=0.001), folds (10.9%, p=0.009), and ≥3 psoriasis body areas (18.8%, p<0.001), but showed more psoriasis family history (67.6%, p=0.001) and a milder overall joint phenotype. The S group associated a worse cardiometabolic profile and developed more dactylitis (44%, p=0.012) during follow-up. The PF group was younger at psoriasis onset (p<0.001), had more extensive psoriasis (p<0.001), and higher frequency of HLA-Cw6 positivity (43.2%). Within the PF group, patients with axial onset [median 19.0 years (IQR: 10.5–25.5)] had a longer psoriasis-arthritis latency compared to other onset forms [median 14.0 years (IQR: 5–24)].
CONCLUSIONS:
In this study, substantial phenotypic differences were identified based on the three PsA lag time models. In addition, the classic pattern of arthritogenic psoriasis did not prevail in the same way between these groups, which was novel.

DOI: https://doi.org/10.55563/clinexprheumatol/8gl4ja

Rheumatology Article