Paediatric Rheumatology
Risk factors and long-term follow-up in acute Kawasaki disease patients with medium or large coronary artery aneurysms
W. Li1, Y. Tong2, X. Xue3, L. Su4, Y.-J. Wu5, X. Xie6, Y. Wang7, M. Tang8, H. Zhang9, L. Hu10, F. Wang11, X. Gu12, Z. Wang13
- Department of Cardiology, Guangzhou Women and Children’s Medical Center, Guangzhou Medical University, Guangzhou, China.
- Department of Molecular Medical Center, Guangzhou Women and Children’s Medical Center, Guangzhou Medical University, Guangzhou, China.
- Department of Cardiology, Guangzhou Women and Children’s Medical Center, Guangzhou Medical University, Guangzhou, China.
- Department of Cardiology, Guangzhou Women and Children’s Medical Center, Guangzhou Medical University, Guangzhou, China.
- Department of Cardiology, Guangzhou Women and Children’s Medical Center, Guangzhou Medical University, Guangzhou, China.
- Department of Cardiology, Guangzhou Women and Children’s Medical Center, Guangzhou Medical University, Guangzhou, China.
- Department of Cardiology, Guangzhou Women and Children’s Medical Center, Guangzhou Medical University, Guangzhou, China.
- Department of Emergency, Dongguan Maternal and Child Health Care Hospital, Guangdong, China.
- Department of Paediatrics, Second Affiliated Hospital of Guangdong Medical University, Guangdong, China.
- Department of Cardiology, Guangzhou Women and Children’s Medical Center, Guangzhou Medical University, Guangzhou, China.
- Department of Clinical Biological Resource Bank, Guangzhou Institute of Paediatrics, Guangdong Provincial Key Laboratory of Research in Structural Birth Defect Disease, Guangzhou Women and Children’s Medical Center, Guangzhou Medical University, Guangzhou, China.
- Department of Clinical Biological Resource Bank, Guangzhou Institute of Paediatrics, Guangdong Provincial Key Laboratory of Research in Structural Birth Defect Disease, Guangzhou Women and Children’s Medical Center, Guangzhou Medical University, Guangzhou, China. guxiaoqiong@gwcmc.org
- Department of Cardiology, Guangzhou Women and Children’s Medical Center, Guangzhou Medical University, Guangzhou, China. wang_zhouping@gwcmc.org
CER19443
Paediatric Rheumatology
Received: 22/10/2025
Accepted : 19/05/2026
In Press: 09/07/2026
Abstract
OBJECTIVES:
Kawasaki disease (KD) is a systemic vasculitis that affects children under the age of five. Comprehensive data on KD patients with medium or large CAA are limited. This study aims to investigate the risk factors and long-term follow-up of KD patients with medium or large CAA in a Chinese cohort.
METHODS:
We performed a cohort study of 220 KD patients including 55 patients associated with medium or large CAA and 165
patients without coronary artery abnormality between January 2015 and April 2020. Univariate and multivariate logistic regression analyses were used to identify risk factors. All enrolled patients were followed up for more than 12 months.
RESULTS:
Days to initial IVIG treatment, IVIG resistance, albumin level and platelet count were independent risk factors for KD patients with medium or large CAA based on multivariate logistic regression analysis. At a mean follow-up duration of 49 months, CAA subgroup analysis showed that 19 medium CAA cases (54.3%) promisingly regressed to normal coronary artery diameter, with the constituent ratios of small, medium, and large CAA being 31.4%, 8.6%, and 5.7%, respectively. In contrast, none of large CAA subgroup returned to normal coronary arteries. The constituent ratio of small, medium and large CAA was 15.0%, 25.0% and 60.0%. Besides, we found that coronary thrombosis occurred in 11 acute-phase cases (20.0%; 2 in the medium CAA, 9 in the large CAA), which increased to 18 cases (32.7%; 5 in the medium CAA, 13 in the large CAA) at the end of follow-up.
CONCLUSIONS:
Days to initial IVIG treatment, IVIG resistance, albumin levels and platelet count were risk factors for KD patients with medium or large CAA. The prognosis of medium or large CAA is not ideal during a long-term follow-up, particularly for large CAA.
