impact factor, citescore
logo
In press
In Press
Recent issue
Recent issue
Recent Supplement
Recent supplement
archives
Archives
articles free
Free to view
Search
Search
 

Review

 

Colchicine in coronary artery disease: limitations and challenges

1, 2, 3, 4, 5

 

  1. Cardio Center, IRCCS Humanitas Research Hospital, Rozzano, Milan; and Department of Biomedical Sciences, Humanitas University, Pieve Emanuele, Milan, Italy.
  2. Cardio Center, IRCCS Humanitas Research Hospital, Rozzano, Milan; and Department of Biomedical Sciences, Humanitas University, Pieve Emanuele, Milan, Italy.
  3. Cardio Center, IRCCS Humanitas Research Hospital, Rozzano, Milan; and Department of Biomedical Sciences, Humanitas University, Pieve Emanuele, Milan, Italy.
  4. Cardio Center, IRCCS Humanitas Research Hospital, Rozzano, Milan; and Department of Biomedical Sciences, Humanitas University, Pieve Emanuele, Milan, Italy.
  5. Cardio Center, IRCCS Humanitas Research Hospital, Rozzano, Milan; and Department of Biomedical Sciences, Humanitas University, Pieve Emanuele, Milan, Italy. giulio.stefanini@hunimed.eu

CER19987
2026 Vol.44, N°7
PI 1312, PF 1318
Review

Free to view
(click on article PDF icon to read the article)

Received: 31/03/2026
Accepted : 26/05/2026
In Press: 07/07/2026
Published: 14/07/2026

Abstract

Colchicine has emerged as a promising anti-inflammatory option for secondary prevention in coronary artery disease, but its role in routine practice remains uncertain. Evidence from randomised trials suggests a more consistent benefit in chronic coronary syndromes and selected post-myocardial infarction populations. In contrast, results in acute coronary syndromes and PCI-related settings have been less convincing. This review summarises the main limitations and unresolved challenges of colchicine use in coronary artery disease, including heterogeneity across trials, lack of biomarker-guided patient selection, uncertainty regarding timing and duration of therapy, and concerns about tolerability, safety, and drug interactions. Current data suggest that colchicine may be useful in selected patients rather than as a universal treatment strategy. Further studies are needed to define its optimal clinical use better and to support a more personalised anti-inflammatory approach.

DOI: https://doi.org/10.55563/clinexprheumatol/hcz3hu

Rheumatology Article