Increased serum levels of nitrotyrosine, a marker for peroxynitrite production, in systemic sclerosis

CER2997
2007 Vol.25, N°2
PI 0281, PF 0286
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PMID: 17543154 [PubMed]

Abstract

OBJECTIVES:
To determine serum levels of nitrotyrosine (NT), an end product of peroxynitrite (ONOO-), and its clinical association in patients with systemic sclerosis (SSc).
METHODS:
Serum NT levels from 25 patients with limited cutaneous SSc (lSSc) and 34 patients with diffuse cutaneous SSc (dSSc) were examined by enzyme-linked immunosorbent assay.
RESULTS:
Serum NT levels were elevated in SSc patients compared with normal controls (n = 27), the levels being similar between lSSc and dSSc patients (P < 0.001). SSc patients with elevated NT had higher serum levels of anti- agalactosyl IgG Ab, IgG and IgA than those with normal NT levels (P < 0.05). NT levels correlated inversely with the percentage diffusion capacity for carbon monoxide (DLco) (P < 0.02, r = -0.414, n = 47).
CONCLUSIONS:
These results suggest that ONOO- may play an important role in the clinical manifestations of SSc, especially vascular damage to the lungs, and that ONOO- may be related to immunological abnormalities in SSc.