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Radiographic progression of rheumatoid arthritis in patients from the Czech National Registry receiving infliximab treatment

K. Pavelka, J. Gatterová, D. Tegzová, K. Jarošová, J. Tomasová Studýnková, A. Svobodník, J. Švihálek, L. Dušek, J. Vencovský


2007 Vol.25, N°4
PI 0540, PF 0545
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PMID: 17888209 [PubMed]


To evaluate the clinical status and radiographic progression in patients with rheumatoid arthritis (RA) being followed by the Czech National Registry of biological treatments.
Patients who failed at least two disease-modifying antirheumatic drugs and had high disease activity (DAS28 > 5.1) were treated with infliximab. Radiographic progression was measured with a modified version of the Sharp score (TSS) after 54 weeks of treatment.
Ninety-nine patients with an average disease duration of 13.7 years were enrolled. The DAS28 dropped from 6.66 to 4.07 (p < 0.001). Before treatment the mean TSS was 90.1 and the mean estimated yearly disease progression was 8.56. After 54 weeks of infliximab, radiographic progression was 4.15 times slower than the estimated rate before treatment and 63 patients did not show any radiographic progression at all. In the remaining 36 patients, the progression rate slowed to 3.8 ± 0.9 from the estimated TSS of 10.9 ± 6.9 before the initiation of treatment (p = 0.011).
Data derived from the Czech National Registry, which reflect general clinical practice, show a significant retardation of radiographic progression in patients treated with anti-TNF and the magnitude of the improvement seen is similar to results from clinical trials.

Rheumatology Article