impact factor, citescore
logo
 

Case Reports

 

Osteomalacia revealing cœliac disease and primary biliary cirrhosis-related Fanconi syndrome in a patient with systemic sclerosis


B. Terrier, F. Fakhouri, A. Berezne, M.-A. Bouldouyre, P. Guilpain, P. Sogni, B. Terris, L.-H. Noël, L. Guillevin, L. Mouthon

 

CER3288
2008 Vol.26, N°3
PI 0467, PF 0470
Case Reports

Free to view
(click on article PDF icon to read the article)

PMID: 18578972 [PubMed]

Abstract

ABSTRACT: Systemic sclerosis (SSc) may affect the gastrointestinal tract and cause very rarely malabsorption syndrome related to bacterial overgrowth. Malabsorption syndrome may be responsible for weight loss, diarrhea, osteomalacia, and iron and vitamins deficiency. We report the case of a SSc patient who developed osteomalacia caused by the combination of two exceptional conditions in the setting of SSc: celiac disease (CD) and primary biliary cirrhosis (PBC)-related Fanconi syndrome. Oral prednisone with angiotensin-converting enzyme inhibitors, was initiated because of active lesions of tubulitis, and led to the complete regression of bone pains, and by the improvement of renal function and regression of the features of proximal tubulopathy. Thus, in the presence of vitamin deficiencies in a patient with SSc, together with a search for malabsorption syndrome secondary to bacterial overgrowth, CD and/or PBC-associated Fanconi syndrome should be investigated.

Rheumatology Article