Case Reports
Sarcoidosis occuring during anti-TNF-α treatment for inflammatory rheumatic diseases: report of two cases
É. Toussirot, É. Pertuiset, B. Kantelip, D. Wendling
CER3289
2008 Vol.26, N°3
PI 0471, PF 0475
Case Reports
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PMID: 18578973 [PubMed]
Abstract
ABSTRACT: Anti-TNF-α agents have been tried in cases of refractory sarcoidosis, giving favourable results. Thus, the occurrence of a granulomatous disease in a patient receiving such drug seems paradoxical. We describe 2 patients with inflammatory rheumatic disease, the first with ankylosing spondylitis, the second with rheumatoid arthritis, under anti-TNF-α treatment (infliximab and etanercept respectively) who developed non-caseating granulomas of the lungs and lymph nodes consistent with the diagnosis of sarcoidosis. Limited and various similar cases have been reported. It is generally considered that these granulomatous diseases are related to the anti-TNF-α agent.
