Case Reports
Drug-induced lupus-like syndrome in ankylosing spondylitis treated with infliximab
A. Mounach, M. Ghazi, A. Nouijai, I. Ghozlani, L. Achemlal, A. Bezza, A. El Maghraoui
CER3482
2008 Vol.26, N°6
PI 1116, PF 1118
Case Reports
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PMID: 19210883 [PubMed]
Abstract
ABSTRACT:Specific antagonists of tumour necrosis factor (TNF-α) have rapidly gained popularity for the treatment of rheumatoid arthritis and ankylosing spondylitis (AS). Reported side effects from these agents include drug-induced autoimmune disorders. The monoclonal antibody against TNF-α, infliximab, has been associated with induction of systemic lupus erythematosus (SLE) in only one patient with AS in the literature. However, there have been no published reports of drug induced lupus-like syndrome (LLS) with positive anti-histone antibodies. We describe a 59-year-old woman with a 12-year history of refractory axial AS who developed signs and symptoms of LLS during treatment with infliximb with positive antinuclear and anti-histone antibodies. On diagnosis of LLS, infliximab was discontinued and the LLS-related symptoms promptly resolved.
