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Investigation of TLR5 and TLR7 as candidate genes for susceptibility to systemic lupus erythematosus
E. Sánchez, J.L. Callejas-Rubio, J.M. Sabio, M.A. Gónzalez-Gay, J. Jimenez-Alonso, L. Micó, E. de Ramón, M. Camps, A. Suarez, C. Gutierrez, R. Garcia-Portales, C. Tolosa, N. Ortego-Centeno, J. Sánchez-Román, F.J. Garcia-Hernández, M.F. Gónzalez-Escribano
CER3537
2009 Vol.27, N°2
PI 0267, PF 0271
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PMID: 19473567 [PubMed]
Abstract
PBJECTIVES:The aim of this study was to evaluate the relevance of genetic variants of TLR5 (rs5744168) and TLR7 (rs179008) gene in systemic lupus erythematosus (SLE) in a Spanish population. MATERIAL AND
METHODS:
Our study population consisted of 752 SLE patients and 1107 healthy controls. All individual were of Spanish Caucasian origin. The TLR5 and TLR7 polymorphisms were genotyped using a PCR system with pre-developed TaqMan allelic discrimination assay.
RESULTS:
No statistically significant differences were observed when the allele and genotype distribution of TLR5 rs5744168 and TLR7 rs179008 polymorphisms was compared between SLE patients and healthy controls. A significant increase frequency in the CC genotype of the TLR5 rs5744168 polymorphism among SLE patients without nephritis was found (93% vs. 87% in SLE patients with nephritis, p=0.03, OR=2.11 95%CI 0.93-3.51). However, this difference did not reach statistical significance in the allele frequencies (p=0.08).
CONCLUSIONS:
These results suggest that the tested variations of TLR5 and TLR7 genes do not confer a relevant role in the susceptibility or severity to SLE in the Spanish population.
