A metabolic aspect of osteoarthritis: lipid as a possible contributor to the pathogenesis of cartilage degradation

CER3552
2009 Vol.27, N°2
PI 0347, PF 0353
Review

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PMID: 19473582 [PubMed]

Abstract

ABSTRACT:Osteoarthritis (OA) is considered to be linked to obesity and body fat mass. Recent investigations, however, are aimed at clarifying the roles of adipose tissue-derived proteins and a wide variety of lipid mediators, including fatty acids, sphingolipids, and eicosanoids, in cartilage degradation in OA, in addition to the effects body weight itself. Here, we review recent progress in studies of OA, focusing on the potential role of lipid mediators in articular cartilage and introducing the concept that `OA is a metabolic disease` in which lipids essentially contribute to the pathophysiology of cartilage degradation.