Serum levels of long pentraxin PTX3 in patients with polymyalgia rheumatica
L. Pulsatelli, G. Peri, P. Macchioni, L. Boiardi, C. Salvarani, F. Cantini, A. Mantovani, R. Meliconi
2010 Vol.28, N°5
PI 0756, PF 0758
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PMID: 20822713 [PubMed]
Accepted : 01/06/2010
In Press: 22/10/2010
To evaluate PTX3 feasibility to provide a prognostic tool in PMR clinical practice.
Circulating PTX3 levels were measured in 93 PMR patients at disease onset and during corticosteroid therapy and in 46 normal controls (NC) by ELISA.
No difference in PTX3 concentrations was observed between NC and PMR either at disease onset and during follow-up or between groups of patients defined according to the presence of recurrence/relapse.
PTX3 serum levels do not increase significantly in active PMR. Further studies on patients with giant-cell arteritis could evaluate whether large vessel involvement may be associated to increased PTX3 levels.