Arterial stiffness and proinflammatory cytokines in fibromyalgia syndrome

CER3790
2010 Vol.28, N°6 ,Suppl.63
PI 0071, PF 0077
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PMID: 21176424 [PubMed]

Received: 19/04/2010
Accepted : 23/06/2010
In Press: 22/12/2010
Published: 20/12/2010

Abstract

OBJECTIVES:
We assessed arterial stiffness and inflammatory cytokine profiles in fibromyalgia syndrome (FMS) patients and analysed the association between them.
METHODS:
Twenty-seven FMS patients and 29 age-matched premenopausal healthy controls were enrolled in this study. Arterial stiffness was assessed by pulse wave velocity (PWV) and augmentation index (AIx) from pulse waveform analysis. Levels of serum interleukin-1β (IL-1β), IL-6, IL-8, and vascular endothelial growth factor (VEGF) were measured by enzymelinked immunosorbent assay, and a colorimetric assay was used for measurement of serum nitric oxide (NO) metabolites (nitrate and nitrite, NOx) level. Statistical analyses included the Mann-Whitney U-test and Spearman`s correlation coefficient analysis.
RESULTS:
Higher AIx and AIx@HR75 (aortic AIx at a heart rate of 75beats/min) were noted in FMS compared to those in the controls after adjustment using covariants (padj=0.023 and padj<0.001). However, there were no differences between the three regional PWVs of the two groups at the aorta-femoral, femoral-dorsalis, and aorta-radialis arteries (padj>0.05 for all). FMS subjects had significantly higher serum IL-8 levels than did the healthy controls (327.9±588.7 vs. 76.4±90.5, padj=0.041). However, there were no significant differences in serum IL-1β, IL-6, VEGF, or NOx levels between the FMS patients and the controls (padj>0.05 of all). Serum IL-8 level did not correlate with PWV and AIx in FMS patients.
CONCLUSIONS:
This study demonstrates higher AIx and IL-8 levels in FMS subjects compared to those of the controls. However, arterial stiffness including AIx in FMS was not determined by the serum IL-8 level.