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Orbital mass as manifestation of Wegener's granulomatosis: an ophthalmologic diagnostic approach


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CER3975
2011 Vol.29, N°1 ,Suppl.64
PI 0035, PF 0039
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PMID: 21385547 [PubMed]

Received: 07/07/2010
Accepted : 11/10/2010
In Press: 11/05/2011
Published: 11/05/2011

Abstract

OBJECTIVES:
Orbital manifestation of Wegener`s granulomatosis is diverse and diagnosis is often difficult. This study aims to improve the diagnostic strategy in orbital Wegener.
METHODS:
A review of the diagnostic process in patients in whom a diagnosis of orbital WG was considered.
RESULTS:
Thirty-three patients were analysed, consisting of 15 patients with orbital WG, 11 with idiopathic orbital inflammation, 6 with orbital sarcoidosis and one with aspergillosis. Diagnostic findings indicating orbital WG were ear/nose/throat involvement, multiple organ system involvement, a positive ANCA, and on histology vasculitis, whereas granulomatous inflammation without signs of vasculitis was more indicative of another orbital disease.
CONCLUSIONS:
The diagnostic process of orbital WG should include CT scanning of the orbit and sinuses, ANCA blood testing, consultation of a rheumatologist, an ophthalmologist, and an ear-nose-throat specialist, and biopsy of an easily accessible, active inflammatory lesion.

Rheumatology Article