Use of methotrexate in the elderly and in patients with compromised renal function

CER4140
2010 Vol.28, N°5 ,Suppl.61
PI 0085, PF 0094
Review

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PMID: 21044439 [PubMed]

Received: 06/09/2010
Accepted : 06/09/2010
In Press: 28/10/2010
Published: 28/10/2010

Abstract

The absorption and distribution of MTX are unchanged in the elderly compared to younger RA patients, while both metabolism and renal/biliary excretion of MTX may be affected by age and should be considered when using this drug. Neither haemodialysis nor peritoneal dialysis effectively clears MTX, although high-flux dialysis may prove to be effective. The efficacy of MTX is equivalent in the young and elderly. The adverse event profile reveals a higher frequency of GI, lower and haematological toxicity in older patents, although the overall profile is not qualitatively different.