Successful outcome of two pregnancies in patients with adult-onset Still's disease treated with IL-1 receptor antagonist (anakinra)

CER4687
2011 Vol.29, N°6
PI 1021, PF 1023
Case Reports

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PMID: 22153586 [PubMed]

Received: 18/04/2011
Accepted : 08/07/2011
In Press: 22/12/2011
Published: 22/12/2011

Abstract

Adult onset Still`s disease (AOSD) is an uncommon, systemic, inflammatory disorder of unknown etiology, characterised by spiking fevers, skin rash, and arthritis. Treatment consists of glucocorticosteroids and immunosuppressive drugs. Over the last few years it has become increasingly evident that treatment with the IL-1 receptor antagonist (IL-1RA) anakinra is highly effective even in patients with intractable disease. So far, there are scant data available on the effects of anakinra in pregnancy. We report two patients with AOSD who successfully gave birth while treated with anakinra during pregnancy.