Paediatric Rheumatology
Frequency of juvenile fibromyalgia syndrome in children with familial Mediterranean fever: effects on depression and quality of life
G. Alayli, D. Durmus, O. Ozkaya, H.E. Sen, G. Genc, O. Kuru
CER4834
2011 Vol.29, N°6 ,Suppl.69
PI 0127, PF 0132
Paediatric Rheumatology
Free to view
(click on article PDF icon to read the article)
PMID: 22243560 [PubMed]
Received: 15/06/2011
Accepted : 27/10/2011
In Press: 03/01/2012
Published: 03/01/2012
Abstract
OBJECTIVES:
To determine the prevalence of juvenile fibromyalgia syndrome (JFMS) in children with familial Mediterranean fever (FMF) and to evaluate quality of life (QoL) and depression.
METHODS:
Ninety-one FMF patients (M/F: 44/47) who fulfilled the Livneh criteria and 60 healthy children (M/F: 27/33) were enrolled in the study. Yunus and Masi`s criteria were used for diagnosis of JFMS. Depression was assessed with Children`s Depression Inventory (CDI) and QoL was evaluated with child and parent reports of Paediatric Quality of Life Inventory 4.0 (PedsQL™).
RESULTS:
While 20 (21.9%) of 91 FMF patients fulfilled JFMS criteria, 2 (3.3%) of the control group met the diagnostic criteria of JFMS (p=0.002). PedsQL™ scores (child self-report and parent-report) of the FMF patients were significantly lower and the depression scores were significantly higher than the healthy controls (p<0.001 for all). When the FMF patients were assigned to two groups as FMF with or without JFMS, patients with JFMS were found to have a higher depression score (p=0.007) and child and parent reports of PedsQL™ 4.0 were lower in the children with JFMS than in the patients without JFMS (p=0.001, p=0.003, respectively).
CONCLUSIONS:
We have determined that JFMS frequency was higher in children with FMF and patients with FMF and JFMS had a poor QoL and were more susceptible to depression. FMF patients with widespread and persistent pain should be evaluated for JFMS in order to avoid unnecessary investigations and inappropriate treatment.