Acute respiratory distress syndrome: an undercover antisynthetase syndrome: a case report and a review of the literature

CER4879
2012 Vol.30, N°3
PI 0424, PF 0428
Case Reports

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PMID: 22704642 [PubMed]

Received: 04/07/2011
Accepted : 06/12/2011
In Press: 26/06/2012
Published: 26/06/2012

Abstract

We present the case of a 48-year-old male with an acute respiratory distress syndrome which later proved to be an unexpected and initial manifestation of antisynthetase syndrome. Recognising this as a rare combination of an acute respiratory failure and a connective tissue disease in a previously asymptomatic subject is possible only by means of diagnostic exclusion. Based on similar case reports, the only way to reverse the disease and minimise the sequelae is to begin long-term immunosuppressive therapy as soon as possible once the diagnosis has been made. A review of similar cases with antibody anti-Jo-1 is presented with the aim of providing clinicians with useful indications for promptly recognising this poorly-defined and life-threatening emergency.