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The clinical efficacy of 3 mg/day prednisone in patients with rheumatoid arthritis: evidence from a randomized, double-blind, placebo-controlled withdrawal clinical trial


 

CER5086
2011 Vol.29, N°5 ,Suppl.68
PI 0073, PF 0076
Brief Papers

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PMID: 22018188 [PubMed]

Received: 15/09/2011
Accepted : 15/09/2011
In Press: 21/10/2011
Published: 21/10/2011

Abstract

A randomised, double-blind, placebo-controlled, withdrawal clinical trial was conducted of prednisone <5 mg/ day versus placebo in 31 patients with rheumatoid arthritis (RA). These patients had been treated with long-term 1–4 mg/day of prednisone, 22 with 3 mg/day, in usual clinical care at a single academic clinical setting. Stable clinical status over 12 weeks prior to screening for the trial was documented quantitatively by patient questionnaire scores. The protocol involved three phases: a) `equivalence` – 1–4 study prednisone 1-mg tablets taken for 12 weeks, to ascertain their efficacy versus the patient`s usual prednisone tablets prior to randomisation; b) `transfer` – substitution of a 1-mg prednisone or identical placebo tablet at a rate of a single 1-mg tablet every 4 weeks (over 0–12 weeks) to the same number as baseline prednisone; c) `comparison` – observation over 24 subsequent weeks taking the same number of either placebo or prednisone tablets as at baseline. The primary outcome was withdrawal due to patient-reported lack of efficacy versus continuation in the trial for 24 weeks. Thirty-one patients were randomised, 15 to prednisone and 16 to placebo, with 3 administrative discontinuations. In `intent-to-treat` analyses, 3/15 prednisone and 11/16 placebo participants withdrew (p=0.03). Among participants eligible for the primary outcome of withdrawal for lack of efficacy, 3/13 prednisone versus 11/15 placebo participants withdrew (p=0.02). No meaningful adverse events were reported, as anticipated. These data document statistically significant differences between the efficacy of 1–4 mg prednisone vs. placebo in only 31 patients, which may suggest a robust treatment effect.

Rheumatology Article