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Learning from HSV-infected mice as a model of Behçet's disease


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CER5106
2012 Vol.30, N°3 ,Suppl.72
PI 0096, PF 0103
Review

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PMID: 22766172 [PubMed]

Received: 19/09/2011
Accepted : 29/11/2011
In Press: 25/09/2012
Published: 19/11/2012

Abstract

Several animal models of Behçet`s disease (BD) have been proposed according to putative etiology. Among these models, the herpes simplex virus (HSV)-induced model produced the most similar disease attributes observe in patients. Inoculation of HSV type 1 to the scratched earlobe of mice produced the appropriate symptoms, including oral, genital, and skin ulcers, eye lesions, arthritis, and intestinal involvement. This HSV-induced BD model is the only continuously used model, to which various therapeutic modalities have been applied.

Rheumatology Article