IL-10 and TNF-α promoter polymorphisms in susceptibility to systemic lupus erythematosus in Taiwan
Y.-J. Lin, L. Wan, C.-M. Huang, J.-C. Sheu, S.-Y. Chen, T.-H. Lin, D.-Y. Chen, K.-C. Hsueh, C.-C. Lai, F.-J. Tsai
2010 Vol.28, N°3
PI 0318, PF 0324
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PMID: 20576226 [PubMed]
Accepted : 04/12/2009
In Press: 23/06/2010
The genetic control of Interleukin-10 (IL-10) and Tumour necrosis factor-α (TNF-α) production and the possible interaction between the two cytokines in influencing SLE susceptibility as well as clinical features has not been completely evaluated in the Taiwanese population.
We investigated the association of IL-10 and TNF-α promoter polymorphisms (-1082, -819 and -592 for IL-10 gene; -308 for TNF-α gene) with SLE in a total of 172 Taiwanese patients and 215 controls.
Our results indicate that IL-10 A/T/A-A/T/A genotype was associated with Taiwanese SLE, whereas no significance was observed between TNF-αgenotype and SLE. Furthermore, the TNF-α G allele frequency of the polymorphism at -308 was significantly decreased in patients with oral ulcers. The combined frequencies of IL-10 A/T/A haplotype and TNF-α G-G genotype were significantly increased in SLE patients. In addition, the combined frequencies of IL-10 A/T/A haplotype and TNF-α G-G genotype were significantly decreased in patients with oral ulcers.
These results suggest a significant correlation of the combined IL-10 and TNF-α genetic polymorphisms contribute to SLE susceptibility and clinical features in the Taiwanese population.