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IL-10 and TNF-α promoter polymorphisms in susceptibility to systemic lupus erythematosus in Taiwan


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CER548
2010 Vol.28, N°3
PI 0318, PF 0324
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PMID: 20576226 [PubMed]

Received: 03/08/2009
Accepted : 04/12/2009
In Press: 23/06/2010
Published: 23/06/2010

Abstract

OBJECTIVES:
The genetic control of Interleukin-10 (IL-10) and Tumour necrosis factor-α (TNF-α) production and the possible interaction between the two cytokines in influencing SLE susceptibility as well as clinical features has not been completely evaluated in the Taiwanese population.
METHODS:
We investigated the association of IL-10 and TNF-α promoter polymorphisms (-1082, -819 and -592 for IL-10 gene; -308 for TNF-α gene) with SLE in a total of 172 Taiwanese patients and 215 controls.
RESULTS:
Our results indicate that IL-10 A/T/A-A/T/A genotype was associated with Taiwanese SLE, whereas no significance was observed between TNF-αgenotype and SLE. Furthermore, the TNF-α G allele frequency of the polymorphism at -308 was significantly decreased in patients with oral ulcers. The combined frequencies of IL-10 A/T/A haplotype and TNF-α G-G genotype were significantly increased in SLE patients. In addition, the combined frequencies of IL-10 A/T/A haplotype and TNF-α G-G genotype were significantly decreased in patients with oral ulcers.
CONCLUSIONS:
These results suggest a significant correlation of the combined IL-10 and TNF-α genetic polymorphisms contribute to SLE susceptibility and clinical features in the Taiwanese population.

Rheumatology Article