Association between systemic non-criteria APS manifestations and antibody type and level: results from the Serbian national cohort study

CER5529
2013 Vol.31, N°2
PI 0234, PF 0242
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PMID: 23306109 [PubMed]

Received: 07/03/2012
Accepted : 18/07/2012
In Press: 07/01/2013
Published: 15/03/2013

Abstract

OBJECTIVES:
The aim of this study was to investigate the importance of aPL type and level for non-criteria-related events in APS patients.
METHODS:
Our study included 374 patients: 260 with PAPS and 114 with APS associated with systemic lupus erythematosus (SLE).
RESULTS:
We discovered significant connection between migraine and LA absence, livedo reticularis and aCL-IgG, skin ulcerations with aCL-IgG and anti-β2GPI-IgM, pseudovasculitis lesions with aCL-IgG, aCL-IgM and anti-β2GPI-IgM, and thrombocytopenia with aCL-IgM, aCL-IgG and anti-β2GPI-IgG. Thrombocytopenia occurred more frequently in patients with more than one aPL. In PAPS, epilepsy correlated with ß2GPI-IgM, migraine with aCL-IgM, and thrombocytopenia with aCL-IgM, aCL-IgG, anti ß2GPI-IgG and LA. Skin ulcerations occurred more frequently in IIc category patients and in patients with high levels of aCL-IgG and anti ß2GPI-IgG. Livedo reticularis was more prominent in PAPS with high levels of aCL-IgG. Significantly higher prevalence of thrombocytopenia was observed in patients with high levels of aCL-IgG and anti ß2GPI-IgG. Epilepsy was related to high levels of anti ß2GPI-IgM and thrombocytopenia in the SAPS was correlated with aCL-IgG. Skin ulcerations were more prevalent in aCL-IgM positive SAPS patients and epilepsy more frequently in SAPS patients with high levels of anti ß2GPI-IgG.
CONCLUSIONS:
Our study showed that certain aPL type with certain level correlated with non-criteria manifestations, suggesting their predictive role.