Full Papers

An analysis of 372 patients with anterior uveitis in a large Ibero-American cohort of spondyloarthritis: the RESPONDIA Group

P.D. Sampaio-Barros, I.A. Pereira, C. Hernández-Cuevas, A. Berman, R. Burgos-Vargas, M.A. Gutierrez, A. Barcelos, J.E. Chávez-Corrales, M. Moreno, D.R. Palleiro, R. Saénz-Castro, I. Stekman, V.F. Azevedo, J.A. Braga-Da-Silva, G. Citera, D. Flores-Alvarado, C.R. Gonçalves, C. Graf, A. Nitsche, J. Saavedra, A.C. Ximenes, J. Vázquez-Mellado, A On Behalf Of The Respondia Group, E. Collantes-Estevez

CER5936
2013 Vol.31, N°4
PI 0484, PF 0489
Full Papers

Free to view
(click on article PDF icon to read the article)

PMID: 23899968 [PubMed]

Received: 28/08/2012
Accepted : 05/11/2012
In Press: 29/07/2013
Published: 29/07/2013

Abstract

OBJECTIVES:
This study analysed the frequency of anterior uveitis (AU) and its correlations in a large cohort of patients with spondyloarthritis (SpA).
METHODS:
A common protocol of investigation was prospectively applied to 2012 SpA patients in 85 centres from 10 Ibero-American countries. Clinical and demographic variables and disease indexes were investigated. Categorical variables were compared by χ2 and Fisher`s exact test, and continuous variables were compared by ANOVA or Kruskal-Wallis test. A value of p<0.05 was considered significant.
RESULTS:
AU was referred by 372 SpA patients (18.5%). AU was statistically associated with inflammatory low back pain (p<0.001), radiographic sacroiliitis (p<0.001), enthesopathies (p=0.004), urethritis/acute diarrhoea (p<0.001), balanitis (p=0.002), hip involvement (p=0.002), HLA-B27 (p=0.003), and higher C-reactive protein (p=0.001), whilst it was negatively associated with the number of painful (p=0.03) and swollen (p=0.005) peripheral joints, psoriatic arthritis (p<0.001), psoriasis (p<0.001), nail involvement (p<0.001), and dactilitis (p=0.062; trend). No association with gender, race, and indices (disease activity, functionality and quality of life) was observed. Logistic regression showed that ankylosing spondylitis (p=0.001) and HLA-B27 (p=0.083; trend) was significantly associated with AU, while extra-articular manifestations (predominantly psoriasis) were negatively associated (p=0.016).
CONCLUSIONS:
Anterior uveitis is a frequent extra-articular manifestation in SpA patients, positively associated with axial involvement and HLA-B27 and negatively associated with peripheral involvement and psoriatic arthritis.