Case Reports
Idiopathic recurrent pericarditis treated successfully with tumour necrosis factor alpha blocking agents (anti-TNF-α)
J.C. Nieto González, I. Monteagudo Saez, F.J. López-Longo, B. Serrano, C. Mata Martínez, L. Carreño Pérez
CER6085
2013 Vol.31, N°5
PI 0776, PF 0778
Case Reports
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PMID: 23711245 [PubMed]
Received: 23/10/2012
Accepted : 27/02/2013
In Press: 27/05/2013
Published: 19/09/2013
Abstract
Idiopathic recurrent pericarditis (IRP) is defined by 2 or more episodes of acute pericarditis of unknown etiology. Either auto-immune or auto-inflammatory diseases are suspected. Usually, non-steroidal anti-inflammatory drugs, colchicine or low dose steroid treatments are effective, however, side effects and/or non-response patients are frequent. We report on three paedriatic patients with IRP from our paediatric rheumatology unit. The patients were non-responders to standard therapy and were treated with tumour necrosis factor alpha blocking agents (anti-TNF-α) and showed significant improvement. In two patients, the treatment was tapered and then stopped following several years of therapy. Symptoms flared in the last patient when therapy was tapered more quickly. We conclude that anti-TNF-α can be useful in selected cases of IRP.