Expression of SDF-1/CXCR4 axis in bone marrow mesenchymal stem cells derived from rheumatoid arthritis-usual interstitial pneumonia

CER6198
2013 Vol.31, N°4
PI 0610, PF 0611
Brief Papers

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PMID: 23710557 [PubMed]

Received: 13/12/2012
Accepted : 21/02/2013
In Press: 27/05/2013
Published: 30/07/2013

Abstract

OBJECTIVES:
To explore the SDF-1/ CXCR4 axis as driving mechanism of bone marrow mesenchymal stem-cells to the injured lung in patients with rheumatoid arthritis associated usual interstitial pneumonia (RA-UIP).
METHODS:
We evaluated the m-RNA expression of SDF-1 and CXCR4 with real-time PCR in bone marrow mesenchymal stem cells of 7 RA-UIP and 10 RA patients without lung involvement.
RESULTS:
The axis was not expressed in RA whereas both SDF-1 and CXCR4 were expressed in RA-UIP [1.93 (1.32, 2.00) and 0.008 (0, 0.01)] respectively.
CONCLUSIONS:
The development of pulmonary fibrosis in RA may be considered as the key event for the migration of stem cells to the injured lung through the SDF-1/CXCR4 axis.