TIR-domain-containing adaptor protein gene TIRAP S180L polymorphism is not increased in Behçet's disease patients in two ethnic cohorts
G. Turunc, D. Coskun, F. Alibaz-Oner, P. Coit, N. Duzgun, E. Alpsoy, S.P. Yentur, C. Salvarani, B. Casali, I. Kötter, T. Ergun, H. Direskeneli, A.H. Sawalha, G. Saruhan-Direskeneli
2013 Vol.31, N°3 ,Suppl.77
PI 0054, PF 0056
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PMID: 24064014 [PubMed]
Accepted : 10/04/2013
In Press: 09/09/2013
The single nucleotide polymorphism (SNP) of TIRAP (Serine 180 leucine, S180L) that is shown to be associated with Behçet`s disease (BD) in a European-derived cohort, but not in Middle Eastern patients is investigated in two other populations.
Two cohorts of BD patients and controls from Turkey (n=797) and Italy (n=633) were genotyped by sequence specific primer-polymerase chain reaction (SSP-PCR) or TaqMan q-PCR assays.
Genotype and allele frequencies in TIRAP S180L (rs8177374) were not different between BD patients and controls in either ethnicity. Furthermore, a meta-analysis between the Turkish and the Italian BD cohorts did not reveal an association between this non-synonymous SNP in TIRAP and BD (meta-analysis OR=0.94, meta-analysis p=0.61, Q statistic heterogeneity p=0.11).
TIRAP S180L gene polymorphism, which was previously shown to be associated with BD in a Caucasian population, has been replicated in either Turkish or Italian population in our study.