Association of vitamin D receptor gene polymorphisms with systemic lupus erythematosus: a meta-analysis
J. Xiong, Z. He, X. Zeng, Y. Zhang, Z. Hu
2014 Vol.32, N°2
PI 0174, PF 0181
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PMID: 24321519 [PubMed]
Accepted : 09/10/2013
In Press: 09/12/2013
Vitamin D receptor gene polymorphisms has been shown to be associated with systemic lupus erythematosus (SLE). Several studies have been published which have investigated the association between VDR gene polymorphisms with SLE risk, but the results have been inconclusive. The study was designed to investigate whether the vitamin D receptor gene polymorphisms are associated with the risk of SLE.
A meta-analysis was conducted on associations between the vitamin D receptor gene polymorphisms and SLE using (1) allele contrast and (2) the recessive, (3) the dominant, and (4) the additive models.
A total of 11 case–control studies of 1683 patients and 1883 unrelated healthy individuals were included. The results of meta-analysis indicated that the BsmI and FokI polymorphisms are associated with increased risk of SLE. The overall ORs are 2.14 [95%CI (1.20-3.82), p=0.01] ( BB + Bb vs. bb) and 1.75 [95%CI(1.03-2.97), P=0.04]( FF + Ff vs. ff), respectively, while the ApaI and TaqI polymorphism were not associated. In subgroup analysis by ethnicity, the increased risk of SLE remained in the Asian subgroup for the BsmI and FokI polymorphism, whereas no significant association was found in other populations for other polymorphisms.
The current study suggested that the BsmI and FokI polymorphism are associated with increased risk of SLE, especially in the Asian population, but further studies are needed to confirm our results.