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Familial Mediterranean fever: a critical digest of the 2012-2013 literature

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2013 Vol.31, N°3 ,Suppl.77
PI 0103, PF 0107

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PMID: 24064023 [PubMed]

Received: 29/07/2013
Accepted : 02/08/2013
In Press: 09/09/2013
Published: 09/09/2013


The year 2012-2013 has been a fertile one in the area of FMF inquiry. Recent studies have led to further insight into the possible mechanisms whereby pyrin mutations might cause the auto-inflammatory phenotype that is characteristic of FMF. Evidence-based guidelines for diagnosis of FMF, including the role of genetic testing, have become available. Risks for colchicine resistance have been partially defined, and a randomised, controlled trial showing efficacy of an interleukin-1 antagonist for treatment of colchicine-resistant or intolerant FMF patients was reported. In this review, we summarise these and other salient findings from the recent FMF literature, and discuss their significance for the clinician.

Rheumatology Article