Cardiothoracic interventions in Behçet's disease

CER6996
2014 Vol.32, N°4 ,Suppl.84
PI 0130, PF 0139
Review

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PMID: 24480592 [PubMed]

Received: 01/10/2013
Accepted : 20/11/2013
In Press: 30/01/2014
Published: 30/09/2014

Abstract

OBJECTIVES:
Cardiothoracic interventions for cardiovascular complications of Behçet`s disease have not been sufficiently elucidated.
METHODS:
A comprehensive literature search of cardiovascular complications of Behçet`s disease was made for year range 2000–2013. The articles on the cardiothoracic procedures for cardiovascular complications of Behçet`s disease were screened and analysed.
RESULTS:
The 221 major cardiothoracic procedures performed in this patient setting included 176 (79.6%) cardiac, 9 (4.1%) thoracic, 31 (14.0%) inter-ventional and 5 (2.3%) hybrid procedures (χ2=478.03, p<0.0001). Of the major cardiac operations, there were 74 (42%) valvular, 58 (33%) aneurysmal, 23 (13.1%) thrombotic, 10 (5.7%) coronary and 11 (6.3%) miscellaneous procedures. The postoperative morbidity, recurrence and mortality rates were 21.4%, 11.7% and 15.0%, and the reintervention rates were 15.4% for recurrence, and 43.2% for morbidity patients. Dehiscence of the prosthetic valve was the major morbidity (52.3%) and the major cause of death (63.6%). The cardiac surgical patients carried the highest mortality rate comparing with thoracic, interventional and hybrid treatment patients.
CONCLUSIONS:
Cardiovascular operations prevailed thoracic and interventional procedures for the cardiovascular complications of Behçet`s disease. Postoperative complications and recurrence rates were high. Aortic valve regurgitation, pulmonary artery aneurysm, and intracardiac and great vessel thrombosis were the most common indications for a cardiothoracic intervention. Dehiscence of the prosthetic valve was the main cause of death of the cardiothoracic interventions. Intense immunosuppressive treatment may reduce the postoperative complications and the need for reinterventions.