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Paediatric Rheumatology

 

Periostin gene variants are associated with disease course and severity in juvenile idiopathic arthritis


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CER7199
2014 Vol.32, N°5
PI 0747, PF 0753
Paediatric Rheumatology

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PMID: 25236364 [PubMed]

Received: 17/12/2013
Accepted : 14/03/2014
In Press: 19/09/2014
Published: 01/10/2014

Abstract

OBJECTIVES:
This study aimed to identify polymorphic variants of the Periostin gene associated with disease severity and clinical course in children with juvenile idiopathic arthritis.
METHODS:
DNA genotyping of 7 single-nucleotide polymorphisms within the periostin gene was performed in 117 patients and their parents and in 102 control samples. Our patients were divided in the following 4 disease categories: 1) persistent oligoarthritis; 2) extended oligoarthritis; 3) polyarthritis; 4) systemic arthritis. Quantitative association analysis was performed in order to test for association between the 7 genetic variants and 18 selected clinical traits.
RESULTS:
A harmful association was observed between the minor allele of rs17197936 and 2 clinical traits, count of joints with active arthritis and count of joints with pain on motion/tenderness, in patients with extended oligoarthritis. Furthermore, the haplotype represented by the minor allele variants of rs3829364, rs6750 and rs9547951 showed an unfavourable association with the above 2 traits plus the following 3 in the whole patient group: juvenile arthritis damage index articular score, childhood health assessment questionnaire score and disease duration.
CONCLUSIONS:
These associations suggest that the variants involved can be regarded as genetic factors influencing some phenotypic aspects of juvenile idiopathic arthritis. Genotyping of this gene may represent a useful tool to identify patients who are at greatest risk of experiencing a poorer long-term outcome.

Rheumatology Article