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CC chemokine receptor polymorphism CCR5Δ32 in Portuguese Behçet's disease patients

A. Bettencourt, B. Leal, C. Carvalho, R. Oliveira, A. Martins Silva, J. Vaz Patto, M. Bastos, L. Costa, P.P. Costa, C. Vasconcelos, J. Correia, B.M. Silva

CER7253
2014 Vol.32, N°4 ,Suppl.84
PI 0072, PF 0074
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PMID: 25268662 [PubMed]

Received: 13/01/2014
Accepted : 14/04/2014
In Press: 30/09/2014
Published: 30/09/2014

Abstract

OBJECTIVES:
To investigate whether CCR5 deletion is associated with susceptibility to Behçet`s disease (BD) in a Portuguese population.
METHODS:
A total of 122 BD patients and 227 ethnically-matched controls were studied. Genotyping of the CCR5Δ32 polymorphisms was performed using polymerase chain reaction product sizing.
RESULTS:
No significant differences were observed in the allelic frequencies of CCR532 between patients and controls (OR=0.820; p=0.512). Stratification for gender and for the presence of HLA-B*51 did not reveal any significant differences.
CONCLUSIONS:
These results indicate that CCR5Δ32 is unlikely to contribute to susceptibility to BD in Portuguese patients. This may be explained by the known functional redundancy of this signalling system.