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Non-HLA genes in ankylosing spondylitis: what meta-analyses have shown?

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2014 Vol.32, N°5
PI 0735, PF 0739

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PMID: 25068597 [PubMed]

Received: 25/02/2014
Accepted : 29/04/2014
In Press: 28/07/2014
Published: 01/10/2014


HLA-B27 association with ankylosing spondylitis (AS) is one of the strongest ever reported in the literature. However, only a small proportion of 5–8% of HLA-B27 positive individuals of the general population develops the disease. In recent years, polymorphisms of many non-HLA genes were reported to be associated with AS. In this review, we summarise the current knowledge of non-HLA genetic factors contributing to AS susceptibility based on meta-analyses in order to overcome the limitations of individual genetic studies e.g. the small samples` sizes, the small samples` origin diversities, and the low statistical power of statistical analyses.

Rheumatology Article