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Diabetes mellitus risk factors in rheumatoid arthritis: a systematic review and meta-analysis

1, 2, 3


  1. Shandong University of Tranditional Chinese Medicine, Jinan, China.
  2. Department of Surgery, Shanghai Jiao Tong University Affiliated First People’s Hospital, Shanghai, China.
  3. The Affiliated Hospital of Shandong University of Traditional Chinese Medicine, Jinan, China.

2015 Vol.33, N°1
PI 0115, PF 0121

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PMID: 25535750 [PubMed]

Received: 13/04/2014
Accepted : 25/07/2014
In Press: 22/12/2014
Published: 04/03/2015


The aim of this study was to investigate the relationship between rheumatoid arthritis (RA) and the occurrence of diabetes mellitus (DM).
A meta-analysis was conducted to explore the risk of DM in RA patients. All relevant studies were identified by searching PUBMED, EMBASE and MEDLINE database prior to 1 January 2014. Pooled risk estimates were calculated with random-effects models using STATA 11.0.
A total of 11 case-control studies and 8 cohort studies were included in the final analysis. The pooled risk estimate of 11 case-control studies showed a statistically significant increased risk of DM prevalence among RA individuals (OR=1.40, 95% CI: 1.34–1.47). The pooled risk estimate of 8 cohort studies also showed a statistically significant increasing risk of DM (RR=1.43, 95%CI: 1.38–1.47). In a subgroup analysis for case-control studies, the pooled risk estimate of individuals with RA increased the incidence of T1DM (type 1 diabetes mellitus) and the incidence of T2DM (type 2 diabetes mellitus) (OR, 4.78 vs. 1.41). In a subgroup analysis for cohort studies, RA was also found to have a statistically significant increasing risk of T2DM (RR=1.24, 95%CI: 1.14–1.35). Begg funnel plot and Egger test showed no evidence of publication bias.
RA is associated with increased risk of DM, including T1DM and T2DM.

Rheumatology Article