The development of the disease activity score (DAS) and the disease activity score using 28 joint counts (DAS28)

CER7932
2014 Vol.32, N°5 ,Suppl.85
PI 0065, PF 0074
Optimisation of rheumatology indices

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PMID: 25365092 [PubMed]

Received: 15/09/2014
Accepted : 16/09/2014
In Press: 30/10/2014
Published: 03/11/2014

Abstract

In rheumatoid arthritis, disease activity cannot be measured using a single variable. The Disease Activity Score (DAS) has been developed as a quantitative index to be able to measure, study and manage disease activity in RA in daily clinical practice, clinical trials, and long term observational studies. The DAS is a continuous measure of RA disease activity that combines information from swollen joints, tender joints, acute phase response and patient self-report of general health. Cut points were developed to classify patients in remission, as well as low, moderate, and severe disease activity in the 1990s. DAS-based EULAR response criteria were primarily developed to be used in clinical trials to classify individual patients as non-, moderate, or good responders, depending on the magnitude of change and absolute level of disease activity at the conclusion of the test.