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FCGR2A, FCGR3A, FCGR3B polymorphisms and susceptibility to rheumatoid arthritis: a meta-analysis

1, 2, 3

 

  1. Division of Rheumatology, Department of Internal Medicine, Korea University College of Medicine, Seoul, Korea.
  2. The Hospital for Rheumatic Diseases, Hanyang University Medical Center, Seoul, Korea.
  3. Division of Rheumatology, Department of Internal Medicine, Korea University College of Medicine, Seoul, Korea.

CER8057
2015 Vol.33, N°5
PI 0647, PF 0654
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PMID: 26314337 [PubMed]

Received: 23/10/2014
Accepted : 23/01/2015
In Press: 27/08/2015
Published: 05/10/2015

Abstract

OBJECTIVES:
The aim of this study is to explore whether Fc gamma receptor (FCGR) polymorphisms are associated with the susceptibility to rheumatoid arthritis (RA).
METHODS:
We conducted a meta-analysis on the association between FCGR2A H131R (rs1801274), FCGR3A F158V (rs396991), and FCGR3B NA1/NA2 polymorphisms and RA susceptibility.
RESULTS:
A total of seventeen studies reported in fourteen articles (4,418 patients with RA and 3,560 controls) were considered in our meta-analysis. In all of the study subjects, meta-analysis indicated an association between RA and FCGR2A R allele (OR=0.877, 95% CI=0.792–0.971, p=0.011). Stratification by ethnicity indicated an association between FCGR2A R allele and RA in Europeans (OR=0.816, 95% CI=0.687–0.968, p=0.020), but not in East Asians (OR=0.900, 95% CI=0.778-1.040, p=0.154). Meta-analysis revealed an association between RA and FCGR3A VV vs. FF genotype in all the study subjects (OR=1.210, 95% CI=1.067–1.479, p=0.006). Stratification by ethnicity indicated an association between FCGR3A VV genotype and RA compared to FF genotype in Europeans (OR=1.350, 95% CI=1.107–1.646, p=0.003), but not in East Asians and South Asians. No association was observed between RA and FCGR3B polymorphisms on performing the meta-analysis.
CONCLUSIONS:
Although no relationship was found between the FCGR3B polymorphism and RA susceptibility, FCGR2A and FCGR3A polymorphisms were found to be associated with RA in Europeans, but not in Asians.

Rheumatology Article