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Review

 

Algo-dysfunctional syndromes: a critical digest of the recent literature

1, 2, 3, 4, 5, 6, 7

 

  1. Rheumatology Unit, L. Sacco University Hospital, Milan, Italy.
  2. IRCCS Galeazzi Orthopaedic Institute, Milan, Italy.
  3. Rheumatology Unit, Department of Clinical and Experimental Medicine, University of Pisa, Italy.
  4. Rheumatology Unit, Department of Clinical and Experimental Medicine, University of Pisa, Italy.
  5. Rheumatology Unit, Department of Internal Medicine and Medical Specialities, La Sapienza University of Rome, Italy.
  6. Rheumatology Department, Polytechnic University of the Marche, Ancona, Italy.
  7. Rheumatology Unit, L. Sacco University Hospital, Milan, Italy.

CER8112
2015 Vol.33, N°1 ,Suppl.88
PI 0102, PF 0108
Review

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PMID: 25786051 [PubMed]

Received: 12/11/2014
Accepted : 19/12/2014
In Press: 18/03/2015
Published: 18/03/2015

Abstract

The etiopathogenesis of the algo-dysfunctional syndromes, which include chronic fatigue syndrome, fibromyalgia and irritable bowel syndrome, is still debated, but it is widely accepted that it is best described by a multifactorial model that include genes, environmental factors such as external infections, inflammation, dietary habits, impaired endogenous cortisol production, the aberrant activation of some areas of the central nervous system, and small peripheral nervous fibre damage. This complexity suggests that they should be managed by means of a multidisciplinary approach involving the use of both pharmacological and non-pharmacological treatments. The aim of this review is to discuss the most recent scientific acquisitions concerning these syndromes and their treatment.

Rheumatology Article