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Gender differences in clinical and angiographic findings of patients with Takayasu arteritis


1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12

 

  1. Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea.
  2. Division of Cardiology, Department of Medicine, Vascular Center, Heart Center, Center for Cardiovascular and Stroke Imaging, Heart Vascular Stroke Institute, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea.
  3. Division of Cardiology, Department of Medicine, Vascular Center, Heart Center, Center for Cardiovascular and Stroke Imaging, Heart Vascular Stroke Institute, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea.
  4. Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea.
  5. Division of Cardiology, Department of Medicine, Vascular Center, Heart Center, Center for Cardiovascular and Stroke Imaging, Heart Vascular Stroke Institute, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea.
  6. Division of Cardiology, Department of Medicine, Vascular Center, Heart Center, Center for Cardiovascular and Stroke Imaging, Heart Vascular Stroke Institute, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea.
  7. Division of Rheumatology, Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea.
  8. Department of Thoracic and Cardiovascular Surgery, Vascular Center, Heart Vascular Stroke Institute, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea.
  9. Division of Vascular Surgery, Department of Surgery, Vascular Center, Heart Vascular Stroke Institute, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea.
  10. Department of Radiology and Center for Imaging Science, Center for Cardiovascular and Stroke Imaging, Heart Vascular Stroke Institute, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea.
  11. Department of Radiology and Center for Imaging Science, Center for Cardiovascular and Stroke Imaging, Heart Vascular Stroke Institute, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea.
  12. Division of Cardiology, Department of Medicine, Vascular Center, Heart Center, Center for Cardiovascular and Stroke Imaging, Heart Vascular Stroke Institute, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea.

CER8318
2015 Vol.33, N°2 ,Suppl.89
PI 0132, PF 0137
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PMID: 26016764 [PubMed]

Received: 26/01/2015
Accepted : 04/05/2015
In Press: 26/05/2015
Published: 26/05/2015

Abstract

OBJECTIVES:
Because Takayasu arteritis (TA) predominantly affects females, few data regarding gender differences have been reported. The aim of the present study is to describe clinical features and angiographic findings of patients with TA according to gender.
METHODS:
According to the 1990 American College of Rheumatology criteria, 294 patients were diagnosed with TA between September 1994 and April 2014 at a single tertiary hospital. We reviewed clinical, laboratory, and radiologic data at the time of diagnosis.
RESULTS:
Among the 294 patients studied, 257 (87.4%) were female (male:female ratio=1:6.9). Female patients had a higher tendency to exhibit blood pressure differences between arms (p=0.595) and a weak pulse at the brachial artery (p=0.063). In male patients, we observed higher serum creatinine levels (p=0.038) and hypertension more frequently (p=0.061) than in females. Females exhibited more common lesions in the thoracic aorta and its branches, while males had more frequent lesions in the abdominal aorta and its branches. An analysis of angiographic classification according to the International TA Conference in Tokyo 1994 classification revealed that male patients had a higher incidence of type IV and females showed a higher incidence of types I, IIa, and IIb.
CONCLUSIONS:
Female patients with TA have more frequent involvement of the thoracic aorta and its branches, whereas involvement of the abdominal aorta and its branches is more common in males. Considering these gender-specific differences, adjustment of diagnostic criteria for TA according to gender may be necessary.

Rheumatology Article