Paediatric Rheumatology
Evaluation of bone mass in children and young adults with juvenile idiopathic arthritis
T. Tang1, X. Tang2, L. Xu3, Y. Huang4, J. Zeng5, Q. Li6
- Department of Nephrology and Immunology, Children’s Hospital of Chongqing Medical University, Chongqing, China.
- Department of Nephrology and Immunology, Children’s Hospital of Chongqing Medical University, Chongqing, China.
- Department of Nephrology and Immunology, Children’s Hospital of Chongqing Medical University, Chongqing, China.
- Department of Nephrology and Immunology, Children’s Hospital of Chongqing Medical University, Chongqing, China.
- Department of Nephrology and Immunology, Children’s Hospital of Chongqing Medical University, Chongqing, China.
- Department of Nephrology and Immunology, Children’s Hospital of Chongqing Medical University, Chongqing, China.
CER8235
2015 Vol.33, N°5
PI 0758, PF 0764
Paediatric Rheumatology
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PMID: 26211456 [PubMed]
Received: 23/12/2014
Accepted : 27/04/2015
In Press: 23/07/2015
Published: 05/10/2015
Abstract
OBJECTIVES:
To examine bone mineral density (BMD) in the spines of patients with juvenile idiopathic arthritis (JIA), and to identify the main predictors of spine BMD.
METHODS:
160 patients with JIA (82 female, 78 male; median age, 8.7±3.9 years (range, 2.2–18.2 years)) who fulfilled the International League of Associations for Rheumatology (ILAR) criteria were enrolled. All subjects underwent an initial dual energy x-ray absorptiometry (DXA) scan of the lumbar spine, while 114 and 87 patients underwent a second and third scan, respectively. The data were compared with those obtained for 114 sex- and age-matched healthy controls.
RESULTS:
The DXA scans revealed that the JIA patients had a significant spine BMD deficit compared with control subjects (p<0.001). Longitudinal comparison of patients revealed no significant short-term improvement in the spine BMD. Spine BMD correlated with the age (p<0.05), subtype (p<0.05), and disease activity (p<0.01), BMI (p=0.001), glucocorticoid (GC) exposure (p< 0.05), methotrexate (MTX) therapy (p<0.05), and non-steroidal anti-inflammatory agents (NSAIDs) (p<0.05), erythrocyte sedimentation rate (ESR) (p<0.01), and C-reactive protein (CRP) levels (p<0.01).
CONCLUSIONS:
Patients with JIA have low bone mass, especially those in the polyarticular group >7 years old with higher disease activity.