impact factor, citescore
logo
In press
In Press
Recent issue
Recent issue
Recent Supplement
Recent supplement
archives
Archives
articles free
Free to view
Search
Search
 

Brief Papers

 

Low prevalence of malignancy in patients with idiopathic inflammatory myopathies in Jordan

1, 2, 3, 4, 5

 

  1. Division of Rheumatology, Department of Internal Medicine, The University of Jordan, Jordan University Hospital, Jordan. kmustafa@ju.edu.jo
  2. Division of Rheumatology, Department of Internal Medicine, King Hussein Medical Center, The Royal Medical Services, Amman, Jordan.
  3. Division of Rheumatology, Department of Internal Medicine, King Hussein Medical Center, The Royal Medical Services, Amman, Jordan.
  4. Division of Rheumatology, Department of Medicine, King Abdullah University Hospital, Jordan University of Science and Technology, Irbid, Jordan.
  5. Department of Community Medicine, Public Health and Family Medicine, Faculty of Medicine, University of Science & Technology, Irbid, Jordan.

CER8267
2015 Vol.33, N°5
PI 0731, PF 0733
Brief Papers

Free to view
(click on article PDF icon to read the article)

PMID: 26344556 [PubMed]

Received: 07/01/2015
Accepted : 04/05/2015
In Press: 31/08/2015
Published: 05/10/2015

Abstract

OBJECTIVES:
To estimate the frequency of malignancy among patients with idiopathic inflammatory myopathies (IIM) in Jordan.
METHODS:
This was a retrospective review of case records of patients with IIM in Jordan.
RESULTS:
We identified 94 cases of IIM, (47 polymyositis (PM) and 47 dermatomyositis (DM)). Sixty-seven (71%) were females and 27 (29%) were males. The mean age at diagnosis was 39.7± 15.7 years (range 17-72), median 40 years and the mean follow-up was 5.05±4.03 years (0.2–19). Malignancy was diagnosed in only 4 patients (4.25%) with IIM. Among patients with DM, malignancy was found in three patients (6.4%).The age-standardised rate was 2.7% (95% confidence interval: 0. 6% to 7.1%). The standardised incidence ratio was 0.998. Diagnosis of associated malignancy was made close to the time of IIM diagnosis. Two male patients had nasopharyngeal carcinoma at the ages of 51 and 59 years, while the other two were female with breast and ovarian cancer at the ages of 40 and 45 years, respectively.
CONCLUSIONS:
Malignancy in association with IIM was found to be low in our cohort in comparison to reports from other countries. The observed number of cancer cases in this group of patients is similar to the expected number of cases that would occur in general population of Jordan. This could be related to younger age of disease onset. The benefits of long-term screening for malignancy in our population are not clear.

Rheumatology Article