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Cumulated organ damage is associated with arterial stiffness in women with systemic lupus erythematosus irrespective of renal function

1, 2, 3, 4, 5, 6, 7

 

  1. Systemic Autoimmune Diseases Unit, Department of Internal Medicine, Virgen de las Nieves University Hospital, Granada, Spain. jomasabio@gmail.com
  2. Systemic Autoimmune Diseases Unit, Department of Internal Medicine, Virgen de las Nieves University Hospital, Granada, Spain.
  3. Systemic Autoimmune Diseases Unit, Department of Internal Medicine, Virgen de las Nieves University Hospital, Granada, Spain.
  4. Systemic Autoimmune Diseases Unit, Department of Internal Medicine, Virgen de las Nieves University Hospital, Granada, Spain.
  5. Systemic Autoimmune Diseases Unit, Department of Internal Medicine, Virgen de las Nieves University Hospital, Granada, Spain.
  6. Department of Statistics, Investigación Biosanitaria de Andalucía Oriental Foundation, Granada, Spain.
  7. Systemic Autoimmune Diseases Unit, Department of Internal Medicine, Virgen de las Nieves University Hospital, Granada, Spain.

CER8378
2016 Vol.34, N°1
PI 0053, PF 0057
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PMID: 26812222 [PubMed]

Received: 16/02/2015
Accepted : 07/07/2015
In Press: 12/01/2016
Published: 10/02/2016

Abstract

OBJECTIVES:
To determine whether there is an association between cumulated organ damage and arterial stiffness in women with systemic lupus erythematosus (SLE) with normal renal function and without renal damage.
METHODS:
Eighty-eight SLE women with normal renal function and without renal damage, and 102 sex- and age-matched controls with no history of coronary heart disease or peripheral arterial disease were studied. Cumulated organ damage and arterial stiffness were measured using the SLICC/ACR Damage Index (SDI) and pulse wave velocity (PWV), respectively. Patients were categorised as with (SDI ≥1) or without cumulated organ damage (SDI=0) and bivariate analyses were performed to compare both groups. A multivariate logistic regression was carried out to analyse the independent factors associated with cumulated organ damage. A multiple linear regression analysis was used to investigate the correlation between SDI and PWV, adjusted for appropriate confounders.
RESULTS:
PWV was signi cantly higher in patients with respect to controls (p=0.007). Also, patients with SDI ≥1 had signi cantly higher PWV than those with SDI=0 (p=0.007). In the multivariate analysis, cumulated organ damage was signi cantly associated with PWV (p=0.006) and obesity (p=0.003). Furthermore, PWV correlated with SDI after adjustment for age, SLE duration, systolic blood pressure, body mass index, renal function, prednisone and homocysteine (r=0.283, p=0.011). Patients with increased PWV were more likely to have organ damage (SDI ≥1) than those with normal PWV (67% vs. 36%, p=0.023).
CONCLUSIONS:
Cumulated organ damage was found to be independently associated with the arterial stiffness in SLE women without renal involvement.

Rheumatology Article