Full Papers
Rationale and design of MUSIC OS-EU: an international observational study of the treatment of postmenopausal women for osteoporosis in Europe and Canada
A. Modi1, S. Sen2, J.D. Adachi3, S. Adami4, B. Cortet5, A.L. Cooper6, P. Geusens7, D. Mellström8, J.P. Weaver9, J.P. Van Den Bergh10, A.M. Nguyen11, P.A. Keown12, A.T. Leung13, S. Sajjan14
- Merck & Co., Inc., Kenilworth, New Jersey, USA.
- Merck & Co., Inc., Kenilworth, New Jersey, USA.
- St. Joseph’s Healthcare and McMaster University, Hamilton, Ontario, Canada.
- Department of Medicine, University of Verona, Verona, Italy.
- Department of Rheumatology, University Hospital of Lille, Lille Cedex, France.
- Bridge Medical Centre Crawley, West Sussex, UK.
- Department of Rheumatology, CAPHRI School for Public Health and Primary Care, Maastricht University, Maastricht, the Netherlands.
- Department of Internal Medicine and Geriatrics, Gothenburg University, Göteborg, Sweden.
- Merck & Co., Inc., Kenilworth, New Jersey, USA.
- VieCuri Medical Centre, Venlo, The Netherlands.
- Merck & Co., Inc., Kenilworth, New Jersey, USA.
- Syreon Corporation, Vancouver, Canada.
- Former employee of Merck & Co., Inc., Kenilworth, New Jersey, USA.
- Merck & Co., Inc., Kenilworth, New Jersey, USA.
CER8408
2015 Vol.33, N°4
PI 0537, PF 0544
Full Papers
Free to view
(click on article PDF icon to read the article)
PMID: 26146786 [PubMed]
Received: 27/02/2015
Accepted : 14/04/2015
In Press: 06/07/2015
Published: 20/07/2015
Abstract
OBJECTIVES:
The Medication Use Patterns, Treatment Satisfaction, and Inadequate Control of Osteoporosis Study (MUSIC OS-EU) was designed to better understand the rate and burden of gastrointestinal (GI) events on clinical and health care outcomes among postmenopausal women with osteoporosis.
METHODS:
MUSIC OS-EU is a prospective, multinational, observational cohort study of postmenopausal women ≥50 years of age diagnosed with osteoporosis and enrolled in physician clinics in six countries: France, Italy, the Netherlands, Sweden, the United Kingdom, and Canada. The MUSIC OS-EU study has three components: (i) a physician survey to describe their management of osteoporotic patients with GI events; (ii) a retrospective chart survey to describe the receipt and type of osteoporosis medication prescribed; and (iii) a prospective cohort study including untreated and treated patients diagnosed with osteoporosis to investigate the rate of GI events and association with osteoporosis medication use patterns, health-related quality of life, treatment satisfaction and resource utilisation among postmenopausal women with osteoporosis.
RESULTS:
Physicians at 97 sites completed the physician questionnaire and data for 716 patients were abstracted for the retrospective chart review. Enrolment and the baseline data collection for the prospective cohort study were conducted between March 2012 and June 2013 for 292 untreated and 2,959 treated patients, of whom 684 were new users and 2,275 were experienced users of oral osteoporosis medications.
CONCLUSIONS:
The results of MUSIC OS-EU will illuminate the association of GI events with the management of osteoporosis and with patient-reported outcomes among postmenopausal women with osteoporosis in Europe and Canada.
