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Diagnostic accuracy of lung ultrasound for interstitial lung disease in patients with connective tissue diseases: a meta-analysis


1, 2, 3

 

  1. Division of Rheumatology, Department of Internal Medicine, Korea University College, Seoul, Korea.
  2. Department of Rheumatology, Hanyang University Hospital for Rheumatic Diseases, Seoul, Korea.
  3. Division of Rheumatology, Department of Internal Medicine, Korea University College, Seoul, Korea. lyhcgh@korea.ac.kr

CER8441
2016 Vol.34, N°1
PI 0011, PF 0016
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PMID: 26812366 [PubMed]

Received: 11/03/2015
Accepted : 02/09/2015
In Press: 20/01/2016
Published: 10/02/2016

Abstract

OBJECTIVES:
The purpose of this study was to evaluate and compare the diagnostic performance of lung ultrasound (US) in respect to high-resolution computed tomography (HRCT) findings in patients with connective tissue disease-associated interstitial lung disease (CTD-ILD).
METHODS:
We searched the Pubmed, Embase, and Cochrane Library databases, and performed a meta-analysis on the diagnostic accuracy of lung US according to B-lines (comet tail sign) and on the correlation coefficients between lung US scores and HRCT Warrick scores in CTD-ILD patients.
RESULTS:
Five studies that included a total of 349 patients were available for this meta-analysis. The pooled sensitivity and specificity of lung US were 91.5% (95% confidence interval [CI]: 84.5–96.0) and 81.3% (95% CI: 74.6–86.9), respectively. The positive likelihood ratio, negative likelihood ratio, and diagnostic odds ratio were 4.100 (2.133–7.879), 0.176 (0.006–0.363), and 34.73 (10.10–99.66), respectively. The area under the curve was 0.915 and the Q* index was 0.848, indicating a high diagnostic accuracy. When all four studies with systemic sclerosis were considered together, the pooled sensitivity and specificity of lung US were 89.5% (95% CI 80.3–95.3) and 79.6% (69.9–87.2), respectively. A significant correlation was found between lung US B-line scores and HRCT Warrick scores in CTD-ILD (correlation coefficient: 0.783; p-value <1 × 10-9).
CONCLUSIONS:
Our meta-analysis of published studies demonstrates that lung US has a high diagnostic accuracy, correlates well with HRCT findings, and plays an important role in the diagnosis of CTD-ILD.

Rheumatology Article