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Utility of FDG-PET/CT in the diagnosis of IgG4-related diseases


1, 2, 3, 4, 5, 6

 

  1. Department of Rheumatology, PLA General Hospital, Beijing, China.
  2. Department of Rheumatology, PLA General Hospital, Beijing, China.
  3. Department of Nuclear Medicine, PLA General Hospital, Beijing, China.
  4. Department of Rheumatology, PLA General Hospital, Beijing, China.
  5. Department of Rheumatology, PLA General Hospital, Beijing, China.
  6. Department of Rheumatology, PLA General Hospital, Beijing, China. jian_jzhu@126.com

CER8472
2016 Vol.34, N°1
PI 0119, PF 0125
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PMID: 26842851 [PubMed]

Received: 22/03/2015
Accepted : 09/09/2015
In Press: 02/02/2016
Published: 10/02/2016

Abstract

OBJECTIVES:
The purpose of this work is to evaluate the usefulness of 18F-fluorodeoxyglucose (FDG) positron emission tomography/computed tomography (PET/CT) imaging in management of IgG4-related disease (IgG4-RD) by retrospective analysis of PET/CT results in IgG4-RD patients.
METHODS:
Twenty-six patients diagnosed with IgG4-RD according to Japanese diagnostic criteria who underwent 18F-FDG-PET/CT scans in the PLA General Hospital from January 2010 to May 2015 were enrolled in the study. Their clinical presentations and 18F-FDG-PET/CT findings were analysed.
RESULTS:
A total of 26 patients (20 men; 6 women) with a mean age of 53.8 years (range 35–71 years) and mean treatment course of 7.1 months (range 0.33–72 months) who underwent 18F-FDG-PET/CT scans were analysed. CRP was relatively low in all patients (mean 0.79 mg/dl). 18F-FDG-PET/CT images confirmed that two or more organs were involved in all patients, and average SUV values for involved organs was 4.14 (range 0.30–8.78). Eleven patients were misdiagnosed with submandibular tumours, pancreatic cancer, pancreatitis, pulmonary interstitial fibrosis, retroperitoneal fibrosis or systemic vasculitis prior to 18F-FDG-PET/CT imaging.
CONCLUSIONS:
18F-FDG-PET/CT imaging is a useful tool for the differential diagnosis of IgG4-RD, and for mapping involved organs, guiding biopsy, and monitoring treatment response.

Rheumatology Article