impact factor, citescore
logo
In press
In Press
Recent issue
Recent issue
Recent Supplement
Recent supplement
archives
Archives
articles free
Free to view
Search
Search
 

Clinical aspects

 

Disease duration and Medsger’s severity score are associated with significant liver fibrosis in patients with systemic sclerosis

1, 2, 3, 4, 5, 6, 7, 8, 9, 10

 

  1. Division of Rheumatology, Department of Internal Medicine, Yonsei University College of Medicine, Seoul, South Korea.
  2. Division of Gastroenterology, Department of Internal Medicine, Yonsei University College of Medicine, Seoul, South Korea, and Liver Cirrhosis Clinical Research Center, Seoul, South Korea.
  3. Division of Gastroenterology, Department of Internal Medicine, Yonsei University College of Medicine, Seoul, South Korea, and Liver Cirrhosis Clinical Research Center, Seoul, South Korea.
  4. Division of Gastroenterology, Department of Internal Medicine, Yonsei University College of Medicine, Seoul, South Korea, and Liver Cirrhosis Clinical Research Center, Seoul, South Korea.
  5. Division of Gastroenterology, Department of Internal Medicine, Yonsei University College of Medicine, Seoul, South Korea, and Liver Cirrhosis Clinical Research Center, Seoul, South Korea.
  6. Division of Rheumatology, Department of Internal Medicine, Yonsei University College of Medicine, Seoul, South Korea.
  7. Division of Rheumatology, Department of Internal Medicine, Yonsei University College of Medicine, Seoul, South Korea.
  8. Division of Rheumatology, Department of Internal Medicine, Yonsei University College of Medicine, Seoul, South Korea.
  9. Division of Gastroenterology, Department of Internal Medicine, Yonsei University College of Medicine, Seoul, South Korea, and Liver Cirrhosis Clinical Research Center, Seoul, South Korea.
  10. Division of Gastroenterology, Department of Internal Medicine, Yonsei University College of Medicine, Seoul, South Korea, and Liver Cirrhosis Clinical Research Center, Seoul, South Korea. ksukorea@yuhs.ac

CER8517
2015 Vol.33, N°4 ,Suppl.91
PI 0068, PF 0074
Clinical aspects

Free to view
(click on article PDF icon to read the article)

PMID: 26243041 [PubMed]

Received: 11/04/2015
Accepted : 15/06/2015
In Press: 05/08/2015
Published: 31/08/2015

Abstract

OBJECTIVES:
We investigated the prevalence and predictors of significant liver fibrosis in patients with systemic sclerosis (SSc) who had no evidences of liver diseases due to viral infection, drug, and heavy alcohol consumption.
METHODS:
A total of 44 SSc patients were recruited. In addition to the clinical and laboratory data, the 2013 College of Rheumatology (ACR)/European League Against Rheumatism (EULAR) classification criteria score, modified Rodnan skin score (mRSS), and Medsger’s severity score (MSS) were analysed. Liver stiffness (LS) was measured using transient elastography to assess the degree of liver fibrosis and 7.4 kPa was adopted as the cut-off value for significant liver fibrosis.
RESULTS:
The median age of patients (38 women) was 54 years and the median disease duration was 41.0 months. The median LS value was 4.6 kPa. The median mRSS and MSS were 7.0 and 5.0, respectively. Six (13.6%) patients had significant liver fibrosis. Disease duration (standardised β=0.375, p=0.018) and MSS (standardised β=0.398, p=0.047) significantly correlated with LS values. In multivariate analysis, disease duration ≥63 months (odds ratio (OR) 19.166, 95% confidence interval 1.090, 336.962, p=0.043) and MSS ≥7 (OR 19.796, 95% confidence interval 1.439, 272.252, p=0.026) independently predicted the presence of significant liver fibrosis.
CONCLUSIONS:
The prevalence of significant liver fibrosis was relatively high (13.6%) and its independent predictors were disease duration and MSS.

Rheumatology Article