Paediatric Rheumatology
Temporal change in prevalence and complications of uveitis associated with juvenile idiopathic arthritis: data from a cross-sectional analysis of a prospective nationwide study
C. Tappeiner1, J. Klotsche2, S. Schenck3, M. Niewerth4, K. Minden5, A. Heiligenhaus6
- German Rheumatism Research Centre Berlin, Leibnitz Institute, Berlin; Department of Ophthalmology at St. Franziskus Hospital, Muenster, Germany; Department of Ophthalmology, Inselspital, University of Bern, Switzerland.
- German Rheumatism Research Centre Berlin, Leibnitz Institute, Berlin; and Charité Universitätsmedizin Berlin, Institute for Social Medicine, Epidemiology and Health Economics, Berlin, Germany.
- German Rheumatism Research Centre Berlin, Leibnitz Institute, Berlin, Germany.
- German Rheumatism Research Centre Berlin, Leibnitz Institute, Berlin, Germany.
- German Rheumatism Research Centre Berlin, Leibnitz Institute, Berlin; and Charité Universitätsmedizin Berlin, Children’s University Hospital, Berlin, Germany.
- Department of Ophthalmology at St. Franziskus Hospital, Münster; and University Duisburg-Essen, Germany.
CER8577
2015 Vol.33, N°6
PI 0936, PF 0944
Paediatric Rheumatology
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PMID: 26517055 [PubMed]
Received: 03/05/2015
Accepted : 23/07/2015
In Press: 30/10/2015
Published: 15/12/2015
Abstract
OBJECTIVES:
To analyse the nationwide prevalence of uveitis in JIA and its complications over a whole decade.
METHODS:
We conducted a prospective, observational and cross-sectional study including all JIA patients from a National Paediatric Rheumatological Database (NPRD) with a uveitis add-on module in Germany (2002-2013). Temporal changes in uveitis prevalence, related secondary complications and anti-inflammatory medication were evaluated.
RESULTS:
A total of 60 centres including 18,555 JIA patients (mean 3,863 patients/year, SD=837) were documented in the NPRD between 2002 and 2013. The mean age of the patients was 11.4±4.6 years, their mean disease duration 4.4±3.7 years. Among them, 66.9% were female and 51.7% ANA positive. Patients’ mean age at arthritis onset was 6.9±4.5 years. Treatment rates with synthetic and biological DMARDs increased during the observation period (sDMARD: 39.8% to 47.2%, bDMARD: 3.3% to 21.8%). Uveitis prevalence decreased significantly from 2002 to 2013 (13.0% to 11.6%, OR = 0.98, p=0.015). The prevalence of secondary uveitis complications also decreased significantly between 2002 and 2013 (33.6% to 23.9%, OR=0.94, p<0.001). Among the complications, the most common ones were posterior synechiae, cataract and band keratopathy. A significant increase in achieving uveitis inactivity was observed at 30.6% in 2002 and 65.3% in 2013 (OR=1.15, p<0.001).
CONCLUSIONS:
Uveitis prevalence and complications significantly decreased between 2002 and 2013. This may be associated with a more frequent use of DMARDs.