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Effects of the oral Janus kinase inhibitor tofacitinib on patient-reported outcomes in patients with active rheumatoid arthritis: results of two Phase 2 randomised controlled trials


1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15

 

  1. Pfizer Inc, Groton, CT, USA. gene.wallenstein@pfizer.com
  2. Pfizer Inc, Groton, CT, USA.
  3. Pfizer Inc, Groton, CT, USA.
  4. Metroplex Clinical Research Center, Dallas, TX, USA.
  5. University of Genoa, Italy.
  6. Metroplex Clinical Research Center, Dallas, TX, USA.
  7. Stanford University, Stanford, CA, USA.
  8. Hospital Clinico Universitario, Santiago de Compostela, Spain.
  9. Pfizer Inc, Groton, CT, USA.
  10. Albany Medical College, Albany, NY, USA.
  11. Pfizer Inc, Groton, CT, USA.
  12. Seoul National University College of Medicine, Seoul, Republic of Korea.
  13. Instituto Nacional de Ciencias Médicas y Nutrición-Salvador Zubirán, Mexico City, Mexico.
  14. Stanford University, Stanford, CA, USA.
  15. Pfizer Inc, Groton, CT, USA.

CER8609
2016 Vol.34, N°3
PI 0430, PF 0442
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PMID: 27156561 [PubMed]

Received: 15/05/2015
Accepted : 02/11/2015
In Press: 28/04/2016
Published: 30/05/2016

Abstract

OBJECTIVES:
Tofacitinib is an oral Janus kinase inhibitor for the treatment of rheumatoid arthritis (RA). Here we investigated the effects of tofacitinib on patient-reported outcomes (PRO) in patients with active RA.
METHODS:
Two, 6-month, double-blind, placebo-controlled Phase 2b studies were performed. The combination study evaluated patients with inadequate response to methotrexate who received tofacitinib 1-15 mg twice daily (BID), 20 mg once daily or placebo, on background methotrexate. In the monotherapy study, patients with inadequate response to disease-modifying anti-rheumatic drugs received tofacitinib 1-15 mg BID, adalimumab 40 mg once every other week or placebo. PROs measured were: Patient’s Assessment of Arthritis Pain (PAAP), Patient’s Assessment of Disease Activity, HAQ-DI, FACIT-F and SF-36.
RESULTS:
In the combination study (n=507), significant improvements (p<0.05) versus placebo were observed at Week 12 in PAAP (visual analogue scale) and HAQ-DI for all tofacitinib groups. In the monotherapy study (n=384), significant improvements in PAAP were observed at Week 12 for tofacitinib 5, 10 and 15 mg BID, and in HAQ-DI for tofacitinib 3, 5, 10 and 15 mg BID. Significant improvements versus placebo were seen at Week 2 in PAAP (both studies) and HAQ‑DI (monotherapy study) with tofacitinib, and were maintained throughout each study. In both studies, improvements in several domains of the SF-36 in the tofacitinib groups were observed at Weeks 12 and 24.
CONCLUSIONS:
In patients with active RA, tofacitinib, either in combination with methotrexate or as monotherapy, demonstrated rapid and sustained improvement in pain, physical functioning and health-related quality of life.

Rheumatology Article