Review
One year in review 2015: systemic lupus erythematosus
G. Mirabelli1, F. Cannarile2, C. Bruni3, R. Vagelli4, R. De Luca5, L. Carli6
- Department of Rheumatology, University of Perugia, Perugia, Italy.
- Department of Rheumatology, University of Perugia, Perugia, Italy.
- Rheumatology Unit, Department of Clinical and Experimental Medicine, University of Florence, Florence, Italy.
- Rheumatology Unit, Department of Clinical and Experimental Medicine, University of Pisa, Italy.
- Rheumatology Unit, Department of Clinical and Experimental Medicine, University of Florence, Florence, Italy.
- Rheumatology Unit, Department of Clinical and Experimental Medicine, University of Pisa, and Genetic, Oncology and Clinical Medicine (GenOMeC) PhD, University of Siena, Italy.
CER8666
2015 Vol.33, N°3
PI 0414, PF 0425
Review
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PMID: 26106941 [PubMed]
Received: 05/06/2015
Accepted : 06/06/2015
In Press: 22/06/2015
Published: 22/06/2015
Abstract
Systemic lupus erythematosus is a multiorgan autoimmune disease with a highly variable clinical course, typically involving women in childbearing age. At present, many aspects of its pathogenesis still remain unclear. Moreover, although a significant increase of patient survival has been observed in the last decades, morbidity and mortality remain high. Finally, SLE impacts negatively on the health-related quality-of-life of patients. Therefore, multiple aspects of SLE still remain challenging and it continues to be the object of both clinical and translational clinical research. Herewith, we provide a critical digest of the recent literature on this topic.
